Antifungal, GMS, ketoconazole, poorly water-soluble, release rate, SLNs
The intention of this research was to fabricate and characterize solid lipid nanoparticles (SLNs) laden with poorly water-soluble ketoconazole for oral or topical preparations. All the formulations were fabricated with different weight ratios of ketoconazole, glycerylmonostearate (GMS) and palmitic acid via the temperature modulated solidification technique. The effect of agitator speed and composition on the droplet-size was tested. The release rate of ketoconazole from SLNs was investigated in comparison with the plain drug powder. Other characterization was acquired using XRD, DSC, SEM, TEM and FTIR techniques. With increasing agitator speed or GMS concentration, the droplet-size was reduced. In particular, an SLN formulation containing ketoconazole, GMS and palmitic acid at the weight ratio of 0.2/1.0/1.0 resulted in the mean dropletsize of 326.5 ± 30 nm at 26000 rpm. The release of the drug from the formulation was about 87% in 15 min.
Abid Mehmood Yousaf, Mehvish Sana, Yasser Shahzad, Talib Hussain, Tariq Mahmood ,Muhammad Jamshaid